Clinical applications of carbamylated hemoglobin in renal diseases
Carbamylated hemoglobin is formed by reaction of isocyanate (urea dissociation product) with valine residues of Hb chains. Different studies demonstrated that carbamylated hemoglobin level is increased in patients with renal impairment. This study concluded that carbamylated hemoglobin level significantly correlates with serum creatinine (r=0.411, moderate positive) and urea level (r=0.408, moderate positive) (p<0.001). This correlation may be important in clinical settings makes carbamylated hemoglobin good biomarker for renal impairment, and may reflect severity and duration of renal impairment. We also found that carbamylated hemoglobin level is not affected by the diabetes state of the patient.
Keywords: Carbamylated hemoglobin, urea dissociation products, renal impairment, kidney biomarkers
Mohamed Abdel-Hady Mashahit, Shahira Morsy El-Shafeey, Hala Sayed El-Toukhy, Ragab Adly Ali, Hossam M. Abdel Aziz, Mahmoud Gamal Ali. Clinical applications of carbamylated hemoglobin in renal diseases. Acta Scientiae et Intellectus, 8(2); 2022, 53-59.
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